An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.

Pearson, Mark S; Bethony, Jeffrey M; Pickering, Darren A; de Oliveira, Luciana M; Jariwala, Amar; Santiago, Helton; Miles, Aaron P; Zhan, Bin; Jiang, Desheng; Ranjit, Najju; Mulvenna, Jason; Tribolet, Leon; Plieskatt, Jordan; Smith, Tracey; Bottazzi, Maria Elena; Jones, Kathryn; Keegan, Brian; Hotez, Peter J; Loukas, Alex

Pearson, Mark S; Bethony, Jeffrey M; Pickering, Darren A; de Oliveira, Luciana M; Jariwala, Amar; Santiago, Helton; Miles, Aaron P; Zhan, Bin; Jiang, Desheng; Ranjit, Najju; Mulvenna, Jason; Tribolet, Leon; Plieskatt, Jordan; Smith, Tracey; Bottazzi, Maria Elena; Jones, Kathryn; Keegan, Brian; Hotez, Peter J; Loukas, Alex.

Affiliation

Pearson MS; Division of Infectious Diseases, Queensland Institute of Medical Research and The Australian Centre for Vaccine Development, Brisbane, Australia.

FASEB J ; 23(9): 3007-19, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19380510

Subject(s)

Antibodies, Helminth/therapeutic use; Cysteine Endopeptidases/immunology; Hookworm Infections/prevention & control; Necator americanus/immunology; Ancylostomatoidea/immunology; Animals; Antibodies, Helminth/administration & dosage; Dogs; Hookworm Infections/therapy; Humans; Intestines/parasitology; Treatment Outcome; Vaccination/methods; Vaccines/pharmacology; Vaccines/therapeutic use; Weight Loss

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Full text: 1 Database: MEDLINE Main subject: Antibodies, Helminth / Cysteine Endopeptidases / Necator americanus / Hookworm Infections Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2009 Type: Article Affiliation country: Australia

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