Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma.

Innes, Anh L; Carrington, Stephen D; Thornton, David J; Kirkham, Sara; Rousseau, Karine; Dougherty, Ryan H; Raymond, Wilfred W; Caughey, George H; Muller, Susan J; Fahy, John V

Innes, Anh L; Carrington, Stephen D; Thornton, David J; Kirkham, Sara; Rousseau, Karine; Dougherty, Ryan H; Raymond, Wilfred W; Caughey, George H; Muller, Susan J; Fahy, John V.

Affiliation

Innes AL; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.

Am J Respir Crit Care Med ; 180(3): 203-10, 2009 Aug 01.

Article in En | MEDLINE | ID: mdl-19423716

Subject(s)

Asthma/metabolism; Mucins/analysis; Mucociliary Clearance/drug effects; Secretory Leukocyte Peptidase Inhibitor/pharmacology; Serine Proteinase Inhibitors/pharmacology; Sputum/chemistry; Acute Disease; Adult; Aged; Asthma/drug therapy; Elasticity; Electrophoresis, Gel, Two-Dimensional; Female; Follow-Up Studies; Humans; Immunoblotting; Male; Middle Aged; Molecular Weight; Sputum/drug effects; Viscosity; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Asthma / Sputum / Serine Proteinase Inhibitors / Mucociliary Clearance / Secretory Leukocyte Peptidase Inhibitor / Mucins Type of study: Observational_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2009 Type: Article Affiliation country: United States

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