A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.

Jones, Chris I; Bray, Sarah; Garner, Stephen F; Stephens, Jonathan; de Bono, Bernard; Angenent, Will G J; Bentley, David; Burns, Philippa; Coffey, Alison; Deloukas, Panos; Earthrowl, Mark; Farndale, Richard W; Hoylaerts, Marc F; Koch, Kerstin; Rankin, Angela; Rice, Catherine M; Rogers, Jane; Samani, Nilesh J; Steward, Michael; Walker, Adam; Watkins, Nicholas A; Akkerman, Jan-Willem; Dudbridge, Frank; Goodall, Alison H; Ouwehand, Willem H

Jones, Chris I; Bray, Sarah; Garner, Stephen F; Stephens, Jonathan; de Bono, Bernard; Angenent, Will G J; Bentley, David; Burns, Philippa; Coffey, Alison; Deloukas, Panos; Earthrowl, Mark; Farndale, Richard W; Hoylaerts, Marc F; Koch, Kerstin; Rankin, Angela; Rice, Catherine M; Rogers, Jane; Samani, Nilesh J; Steward, Michael; Walker, Adam; Watkins, Nicholas A; Akkerman, Jan-Willem; Dudbridge, Frank; Goodall, Alison H; Ouwehand, Willem H.

Affiliation

Jones CI; Department of Cardiovascular Science, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, United Kingdom.

Blood ; 114(7): 1405-16, 2009 Aug 13.

Article in En | MEDLINE | ID: mdl-19429868

Subject(s)

Blood Platelets/physiology; Cell Degranulation/genetics; Gene Expression Regulation/physiology; Platelet Activation/genetics; Quantitative Trait Loci/physiology; Signal Transduction/genetics; 3' Untranslated Regions/genetics; 3' Untranslated Regions/metabolism; Adenosine Diphosphate/genetics; Adenosine Diphosphate/metabolism; Alleles; Blood Platelets/cytology; Collagen/genetics; Collagen/metabolism; Europe; Female; Genomics; Genotype; Humans; Inositol 1,4,5-Trisphosphate Receptors/biosynthesis; Inositol 1,4,5-Trisphosphate Receptors/genetics; Male; P-Selectin/genetics; P-Selectin/metabolism; Polymorphism, Single Nucleotide; Receptors, Cell Surface/biosynthesis; Receptors, Cell Surface/genetics; White People

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Full text: 1 Database: MEDLINE Main subject: Blood Platelets / Signal Transduction / Cell Degranulation / Platelet Activation / Gene Expression Regulation / Quantitative Trait Loci Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Blood Year: 2009 Type: Article Affiliation country: United kingdom

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