HLA-B27-restricted antigen presentation by human chondrocytes to CD8+ T cells: potential contribution to local immunopathologic processes in ankylosing spondylitis.

Kuhne, Maren; Erben, Ulrike; Schulze-Tanzil, Gundula; Köhler, Dorothee; Wu, Peihua; Richter, F Jan; John, Thilo; Radbruch, Andreas; Sieper, Joachim; Appel, Heiner

Kuhne, Maren; Erben, Ulrike; Schulze-Tanzil, Gundula; Köhler, Dorothee; Wu, Peihua; Richter, F Jan; John, Thilo; Radbruch, Andreas; Sieper, Joachim; Appel, Heiner.

Affiliation

Kuhne M; Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany.

Arthritis Rheum ; 60(6): 1635-46, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19479861

Subject(s)

CD8-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/pathology; Cell Communication/physiology; Chondrocytes/metabolism; Chondrocytes/pathology; HLA-B27 Antigen/metabolism; Spondylitis, Ankylosing/immunology; B7-1 Antigen/metabolism; Cartilage, Articular/metabolism; Cartilage, Articular/pathology; Cell Line; Cells, Cultured; Chondrocytes/drug effects; Collagen Type II/metabolism; Female; Granzymes/metabolism; Humans; Interferon-gamma/pharmacology; Middle Aged; Perforin/metabolism; Spondylitis, Ankylosing/pathology; Spondylitis, Ankylosing/physiopathology

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Full text: 1 Database: MEDLINE Main subject: Spondylitis, Ankylosing / HLA-B27 Antigen / Cell Communication / CD8-Positive T-Lymphocytes / Chondrocytes Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Arthritis Rheum Year: 2009 Type: Article Affiliation country: Germany

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