Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats.

Zhong, Jin; Zhao, Limin; Du, Yansheng; Wei, Gang; Yao, Wei-Guo; Lee, Wei-Hua

Zhong, Jin; Zhao, Limin; Du, Yansheng; Wei, Gang; Yao, Wei-Guo; Lee, Wei-Hua.

Affiliation

Zhong J; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Neurol Res ; 31(5): 483-9, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19500451

Subject(s)

Cell Survival/physiology; Cytoprotection/physiology; Hypoxia-Ischemia, Brain/physiopathology; Insulin-Like Growth Factor I/pharmacology; Neuroprotective Agents/pharmacology; Recovery of Function/drug effects; Animals; Animals, Newborn; Apoptosis/drug effects; Apoptosis/physiology; Blotting, Western; Brain/pathology; Brain Injuries/etiology; Brain Injuries/physiopathology; Cell Survival/drug effects; Cells, Cultured; Cytoprotection/drug effects; Female; Hypoxia-Ischemia, Brain/complications; Hypoxia-Ischemia, Brain/prevention & control; Maze Learning/drug effects; Memory; Neurons/drug effects; Pregnancy; Rats; Rats, Sprague-Dawley; Signal Transduction/drug effects

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Full text: 1 Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Cell Survival / Neuroprotective Agents / Cytoprotection / Recovery of Function / Hypoxia-Ischemia, Brain Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Neurol Res Year: 2009 Type: Article Affiliation country: United States

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