The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

Li, Suiyang; Brignole, Claudine; Marcellus, Richard; Thirlwell, Sara; Binda, Olivier; McQuoid, Monica J; Ashby, Danita; Chan, Helen; Zhang, Zhiying; Miron, Marie-Joëlle; Pallas, David C; Branton, Philip E

Li, Suiyang; Brignole, Claudine; Marcellus, Richard; Thirlwell, Sara; Binda, Olivier; McQuoid, Monica J; Ashby, Danita; Chan, Helen; Zhang, Zhiying; Miron, Marie-Joëlle; Pallas, David C; Branton, Philip E.

Affiliation

Li S; Department of Biochemistry, Goodman Cancer Centre, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6.

J Virol ; 83(17): 8340-52, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19535438

Subject(s)

Adenoviruses, Human/pathogenicity; Cell Cycle; Cell Death; Protein Phosphatase 2/antagonists & inhibitors; Viral Proteins/metabolism; Cell Count; Cell Line, Tumor; Cell Survival; Humans; Protein Binding; Protein Phosphatase 2/metabolism

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Full text: 1 Database: MEDLINE Main subject: Viral Proteins / Cell Cycle / Adenoviruses, Human / Cell Death / Protein Phosphatase 2 Limits: Humans Language: En Journal: J Virol Year: 2009 Type: Article

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