MFTZ-1 reduces constitutive and inducible HIF-1&#945; accumulation and VEGF secretion independent of its topoisomerase II inhibition.

Dai, Mei; Miao, Ze-Hong; Ren, Xuan; Tong, Lin-Jiang; Yang, Na; Li, Ting; Lin, Li-Ping; Shen, Yue-Mao; Ding, Jian

MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.

Dai, Mei; Miao, Ze-Hong; Ren, Xuan; Tong, Lin-Jiang; Yang, Na; Li, Ting; Lin, Li-Ping; Shen, Yue-Mao; Ding, Jian.

Affiliation

Dai M; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.

J Cell Mol Med ; 14(9): 2281-91, 2010 Sep.

Article in En | MEDLINE | ID: mdl-19538463

Subject(s)

DNA Topoisomerases, Type II/metabolism; Eicosanoids/pharmacology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Macrolides/pharmacology; Topoisomerase II Inhibitors/pharmacology; Vascular Endothelial Growth Factor A/metabolism; Animals; Cell Line, Tumor; Eicosanoids/therapeutic use; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Macrolides/therapeutic use; Mitogen-Activated Protein Kinases/metabolism; Neovascularization, Pathologic/drug therapy; Phosphatidylinositol 3-Kinases/metabolism; Proteasome Endopeptidase Complex/metabolism; Protein Processing, Post-Translational/drug effects; Proto-Oncogene Proteins c-akt/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction/drug effects; Transcription, Genetic/drug effects

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Full text: 1 Database: MEDLINE Main subject: Eicosanoids / DNA Topoisomerases, Type II / Macrolides / Vascular Endothelial Growth Factor A / Hypoxia-Inducible Factor 1, alpha Subunit / Topoisomerase II Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2010 Type: Article

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