TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.

Imamachi, Noritaka; Park, Goon Ho; Lee, Hyosang; Anderson, David J; Simon, Melvin I; Basbaum, Allan I; Han, Sang-Kyou

Imamachi, Noritaka; Park, Goon Ho; Lee, Hyosang; Anderson, David J; Simon, Melvin I; Basbaum, Allan I; Han, Sang-Kyou.

Affiliation

Imamachi N; Department of Anatomy, University of California, San Francisco, CA 94143, USA.

Proc Natl Acad Sci U S A ; 106(27): 11330-5, 2009 Jul 07.

Article in En | MEDLINE | ID: mdl-19564617

Subject(s)

Behavior, Animal; Neurons, Afferent/metabolism; Pruritus/metabolism; TRPV Cation Channels/metabolism; Animals; Behavior, Animal/drug effects; Endothelin-1/administration & dosage; Endothelin-1/pharmacology; Injections; Mice; Mice, Inbred C57BL; Models, Biological; Mutation/genetics; Neurons, Afferent/drug effects; Neurons, Afferent/enzymology; Nociceptors/metabolism; Pain/metabolism; Phospholipase C beta/deficiency; Phospholipase C beta/metabolism; Physical Stimulation; Posterior Horn Cells/drug effects; Posterior Horn Cells/metabolism; Posterior Horn Cells/pathology; Proto-Oncogene Proteins c-fos/metabolism; Serotonin/administration & dosage; Serotonin/analogs & derivatives; Serotonin/pharmacology; Temperature

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Full text: 1 Database: MEDLINE Main subject: Pruritus / Behavior, Animal / TRPV Cation Channels / Neurons, Afferent Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Type: Article Affiliation country: United States

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