Inhibition of PI3K and MEK: it is all about combinations and biomarkers.

Rexer, Brent N; Ghosh, Ritwik; Arteaga, Carlos L

Rexer, Brent N; Ghosh, Ritwik; Arteaga, Carlos L.

Affiliation

Rexer BN; Department of Medicine, Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center; Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6307, USA.

Clin Cancer Res ; 15(14): 4518-20, 2009 Jul 15.

Article in En | MEDLINE | ID: mdl-19584146

Subject(s)

Breast Neoplasms/drug therapy; Enzyme Inhibitors/pharmacology; MAP Kinase Kinase 1/antagonists & inhibitors; Phosphoinositide-3 Kinase Inhibitors; Xenograft Model Antitumor Assays; Animals; Antineoplastic Agents/pharmacology; Biomarkers, Tumor/antagonists & inhibitors; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Female; Humans; MAP Kinase Kinase 1/genetics; MAP Kinase Kinase 1/metabolism; Mammary Neoplasms, Experimental/drug therapy; Mammary Neoplasms, Experimental/metabolism; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Inbred Strains; Mice, Nude; Models, Biological; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Xenograft Model Antitumor Assays / MAP Kinase Kinase 1 / Enzyme Inhibitors / Phosphoinositide-3 Kinase Inhibitors Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2009 Type: Article Affiliation country: United States

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