Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.

Lynch, Heather E; Ray, Caroline A; Oie, Katrina L; Pollara, Justin J; Petty, Ian T D; Sadler, Anthony J; Williams, Bryan R G; Pickup, David J

Lynch, Heather E; Ray, Caroline A; Oie, Katrina L; Pollara, Justin J; Petty, Ian T D; Sadler, Anthony J; Williams, Bryan R G; Pickup, David J.

Affiliation

Lynch HE; Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA. heather.lynch@duke.edu

Virology ; 391(2): 177-86, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19596385

Subject(s)

NF-kappa B/biosynthesis; Vaccinia virus/immunology; Vaccinia virus/physiology; Virus Replication; eIF-2 Kinase/immunology; Animals; Cell Line; Cricetinae; Humans; I-kappa B Proteins/antagonists & inhibitors; Mice; NF-KappaB Inhibitor alpha

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Full text: 1 Database: MEDLINE Main subject: Vaccinia virus / Virus Replication / NF-kappa B / EIF-2 Kinase Limits: Animals / Humans Language: En Journal: Virology Year: 2009 Type: Article Affiliation country: United States

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