Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.

Markovic, D S; Vinnakota, K; Chirasani, S; Synowitz, M; Raguet, H; Stock, K; Sliwa, M; Lehmann, S; Kälin, R; van Rooijen, N; Holmbeck, K; Heppner, F L; Kiwit, J; Matyash, V; Lehnardt, S; Kaminska, B; Glass, R; Kettenmann, H

Markovic, D S; Vinnakota, K; Chirasani, S; Synowitz, M; Raguet, H; Stock, K; Sliwa, M; Lehmann, S; Kälin, R; van Rooijen, N; Holmbeck, K; Heppner, F L; Kiwit, J; Matyash, V; Lehnardt, S; Kaminska, B; Glass, R; Kettenmann, H.

Affiliation

Markovic DS; Cellular Neuroscience, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.

Proc Natl Acad Sci U S A ; 106(30): 12530-5, 2009 Jul 28.

Article in En | MEDLINE | ID: mdl-19617536

Subject(s)

Glioma/pathology; Matrix Metalloproteinase 14/metabolism; Microglia/pathology; Animals; Blotting, Western; Brain Neoplasms/genetics; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Line, Tumor; Enzyme Precursors/metabolism; Female; Gelatinases/metabolism; Gene Expression Regulation, Neoplastic; Glioma/genetics; Glioma/metabolism; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 14/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia/metabolism; Myeloid Differentiation Factor 88/genetics; Myeloid Differentiation Factor 88/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Toll-Like Receptors/metabolism; Tumor Burden; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Microglia / Matrix Metalloproteinase 14 / Glioma Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Type: Article Affiliation country: Germany

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