Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen.

Calmels, Nadège; Seznec, Hervé; Villa, Pascal; Reutenauer, Laurence; Hibert, Marcel; Haiech, Jacques; Rustin, Pierre; Koenig, Michel; Puccio, Hélène

Calmels, Nadège; Seznec, Hervé; Villa, Pascal; Reutenauer, Laurence; Hibert, Marcel; Haiech, Jacques; Rustin, Pierre; Koenig, Michel; Puccio, Hélène.

Affiliation

Calmels N; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), CNRS/INSERM/Université Louis Pasteur, Illkirch cedex, France. nadege.calmels@chru-strasbourg.fr

BMC Neurol ; 9: 46, 2009 Aug 24.

Article in En | MEDLINE | ID: mdl-19703283

Subject(s)

Drug Evaluation, Preclinical; Friedreich Ataxia/drug therapy; Iron-Binding Proteins/genetics; Animals; Blotting, Western; Cell Line/cytology; Cell Proliferation; Cells, Cultured; Friedreich Ataxia/genetics; Friedreich Ataxia/metabolism; Gene Knockdown Techniques; Iron-Sulfur Proteins/genetics; Iron-Sulfur Proteins/metabolism; Mice; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Frataxin

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Full text: 1 Database: MEDLINE Main subject: Friedreich Ataxia / Iron-Binding Proteins / Drug Evaluation, Preclinical Type of study: Prognostic_studies Limits: Animals Language: En Journal: BMC Neurol Journal subject: NEUROLOGIA Year: 2009 Type: Article Affiliation country: France

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