Pyrazole NNRTIs 1: design and initial optimisation of a novel template.

Mowbray, Charles E; Burt, Catherine; Corbau, Romuald; Perros, Manos; Tran, Isabelle; Stupple, Paul A; Webster, Rob; Wood, Anthony

Mowbray, Charles E; Burt, Catherine; Corbau, Romuald; Perros, Manos; Tran, Isabelle; Stupple, Paul A; Webster, Rob; Wood, Anthony.

Affiliation

Mowbray CE; Department of Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. Charles.Mowbray@Pfizer.Com

Bioorg Med Chem Lett ; 19(19): 5599-602, 2009 Oct 01.

Article in En | MEDLINE | ID: mdl-19709880

Subject(s)

Anti-HIV Agents/chemistry; HIV Reverse Transcriptase/antagonists & inhibitors; Pyrazoles/chemistry; Reverse Transcriptase Inhibitors/chemistry; Anti-HIV Agents/chemical synthesis; Anti-HIV Agents/pharmacology; Drug Design; HIV Reverse Transcriptase/metabolism; Humans; Microsomes, Liver/metabolism; Pyrazoles/chemical synthesis; Pyrazoles/pharmacology; Reverse Transcriptase Inhibitors/chemical synthesis; Reverse Transcriptase Inhibitors/pharmacology; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Reverse Transcriptase Inhibitors / Anti-HIV Agents / HIV Reverse Transcriptase Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United kingdom

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