Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.

Kozell, Laura B; Walter, Nicole A R; Milner, Lauren C; Wickman, Kevin; Buck, Kari J

Kozell, Laura B; Walter, Nicole A R; Milner, Lauren C; Wickman, Kevin; Buck, Kari J.

Affiliation

Kozell LB; Department of Behavioral Neuroscience, Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon 97239-3098, USA.

J Neurosci ; 29(37): 11662-73, 2009 Sep 16.

Article in En | MEDLINE | ID: mdl-19759313

Subject(s)

Chromosome Mapping; Ethanol/adverse effects; G Protein-Coupled Inwardly-Rectifying Potassium Channels/physiology; Pentobarbital/adverse effects; Pyridines/adverse effects; Substance Withdrawal Syndrome/genetics; Animals; Area Under Curve; Behavior, Animal; Brain/metabolism; Brain/pathology; Chromosomes, Human, Pair 1; DNA Mutational Analysis; Disease Models, Animal; G Protein-Coupled Inwardly-Rectifying Potassium Channels/deficiency; Gene Expression Regulation/genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Polymorphism, Single Nucleotide/genetics; Quantitative Trait Loci; Substance Withdrawal Syndrome/pathology; Zolpidem

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Full text: 1 Database: MEDLINE Main subject: Pentobarbital / Pyridines / Substance Withdrawal Syndrome / Chromosome Mapping / Ethanol / G Protein-Coupled Inwardly-Rectifying Potassium Channels Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neurosci Year: 2009 Type: Article Affiliation country: United States

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