Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.

Pippel, Marna; Boyce, Kristen; Venkatesan, Hariharan; Phuong, Victor K; Yan, Wen; Barrett, Terrance D; Lagaud, Guy; Li, Lina; Morton, Magda F; Prendergast, Clodagh; Wu, Xiaodong; Shankley, Nigel P; Rabinowitz, Michael H

Pippel, Marna; Boyce, Kristen; Venkatesan, Hariharan; Phuong, Victor K; Yan, Wen; Barrett, Terrance D; Lagaud, Guy; Li, Lina; Morton, Magda F; Prendergast, Clodagh; Wu, Xiaodong; Shankley, Nigel P; Rabinowitz, Michael H.

Affiliation

Pippel M; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

Bioorg Med Chem Lett ; 19(22): 6376-8, 2009 Nov 15.

Article in En | MEDLINE | ID: mdl-19815410

Subject(s)

Isoxazoles/chemistry; Receptor, Cholecystokinin A/antagonists & inhibitors; Receptor, Cholecystokinin B/antagonists & inhibitors; Signal Transduction/drug effects; Sulfonamides/pharmacology; Amino Acid Substitution; Animals; Models, Molecular; Rats; Rats, Wistar; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Sulfonamides / Signal Transduction / Receptor, Cholecystokinin A / Receptor, Cholecystokinin B / Isoxazoles Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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