Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim, Woo-Kyun; Meliton, Vicente; Tetradis, Sotirios; Weinmaster, Gerry; Hahn, Theodore J; Carlson, Marc; Nelson, Stanley F; Parhami, Farhad

Kim, Woo-Kyun; Meliton, Vicente; Tetradis, Sotirios; Weinmaster, Gerry; Hahn, Theodore J; Carlson, Marc; Nelson, Stanley F; Parhami, Farhad.

Affiliation

Kim WK; Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA.

J Bone Miner Res ; 25(4): 782-95, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19839776

Subject(s)

Bone Marrow Cells/drug effects; Gene Expression/drug effects; Hydroxycholesterols/pharmacology; Osteogenesis/drug effects; Receptors, Notch/genetics; Animals; Basic Helix-Loop-Helix Transcription Factors/analysis; Basic Helix-Loop-Helix Transcription Factors/metabolism; Bone Marrow Cells/metabolism; Cell Culture Techniques; Cell Cycle Proteins/analysis; Cell Cycle Proteins/metabolism; Fibroblasts/drug effects; Fibroblasts/metabolism; Hedgehog Proteins/metabolism; Homeodomain Proteins/analysis; Homeodomain Proteins/metabolism; Liver X Receptors; Mice; Orphan Nuclear Receptors/analysis; Orphan Nuclear Receptors/metabolism; RNA, Messenger/analysis; RNA, Messenger/metabolism; Stromal Cells/drug effects; Stromal Cells/metabolism; Transcription Factor HES-1; Veratrum Alkaloids/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Osteogenesis / Bone Marrow Cells / Gene Expression / Receptors, Notch / Hydroxycholesterols Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2010 Type: Article Affiliation country: United States

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