Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease.

Kichev, Anton; Ilieva, Ekaterina V; Piñol-Ripoll, Gerard; Podlesniy, Petar; Ferrer, Isidro; Portero-Otín, Manuel; Pamplona, Reinald; Espinet, Carme

Kichev, Anton; Ilieva, Ekaterina V; Piñol-Ripoll, Gerard; Podlesniy, Petar; Ferrer, Isidro; Portero-Otín, Manuel; Pamplona, Reinald; Espinet, Carme.

Affiliation

Kichev A; Department of Basic Medical Sciences, University of Lleida-IRBLLEIDA, Lleida, Spain.

Am J Pathol ; 175(6): 2574-85, 2009 Dec.

Article in En | MEDLINE | ID: mdl-19893045

Subject(s)

Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Apoptosis/physiology; Nerve Growth Factor/metabolism; Oxidative Stress/physiology; Protein Precursors/metabolism; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Female; Glycation End Products, Advanced/metabolism; Humans; Immunoprecipitation; In Vitro Techniques; Learning Disabilities/metabolism; Male; Mice; Middle Aged; PC12 Cells; Rats; Receptor, Nerve Growth Factor/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Protein Precursors / Apoptosis / Oxidative Stress / Nerve Growth Factor / Alzheimer Disease Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Am J Pathol Year: 2009 Type: Article Affiliation country: Spain

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google