Ellagic acid derivatives from Syzygium cumini stem bark: investigation of their antiplasmodial activity.
Nat Prod Commun
; 4(10): 1371-6, 2009 Oct.
Article
in En
| MEDLINE
| ID: mdl-19911574
ABSTRACT
Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-alpha-L-2"-acetylrhamnopyranoside, 3-O-methylellagic acid 3'-O-alpha-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3'-O-beta-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of beta-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit beta-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.
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Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Syzygium
/
Plant Bark
/
Ellagic Acid
/
Antimalarials
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Prod Commun
Journal subject:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Year:
2009
Type:
Article
Affiliation country:
Switzerland