Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.

Luciani, Alessandro; Villella, Valeria Rachela; Vasaturo, Angela; Giardino, Ida; Pettoello-Mantovani, Massimo; Guido, Stefano; Cexus, Olivier N; Peake, Nick; Londei, Marco; Quaratino, Sonia; Maiuri, Luigi

Luciani, Alessandro; Villella, Valeria Rachela; Vasaturo, Angela; Giardino, Ida; Pettoello-Mantovani, Massimo; Guido, Stefano; Cexus, Olivier N; Peake, Nick; Londei, Marco; Quaratino, Sonia; Maiuri, Luigi.

Affiliation

Luciani A; Institute of Pediatrics, University of Foggia, viale Pinto 1, Foggia 71100, Italy. maiuri@unina.it

Gut ; 59(3): 311-9, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19951908

Subject(s)

Celiac Disease/metabolism; Gliadin/metabolism; Lysosomes/metabolism; PPAR gamma/metabolism; Peptide Fragments/metabolism; Transglutaminases/physiology; Adolescent; Adult; Down-Regulation/physiology; Epithelial Cells/metabolism; GTP-Binding Proteins; Humans; Intestinal Mucosa/metabolism; Organ Culture Techniques; Oxidative Stress/physiology; Proteasome Endopeptidase Complex/metabolism; Protein Glutamine gamma Glutamyltransferase 2; Reactive Oxygen Species/metabolism; Tumor Cells, Cultured; Ubiquitin/metabolism; Young Adult

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Peptide Fragments / Celiac Disease / Transglutaminases / PPAR gamma / Gliadin / Lysosomes Limits: Adolescent / Adult / Humans Language: En Journal: Gut Year: 2010 Type: Article Affiliation country: Italy

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google