Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.

Briand, François; Tréguier, Morgan; André, Agnès; Grillot, Didier; Issandou, Marc; Ouguerram, Khadija; Sulpice, Thierry

Briand, François; Tréguier, Morgan; André, Agnès; Grillot, Didier; Issandou, Marc; Ouguerram, Khadija; Sulpice, Thierry.

Affiliation

Briand F; Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, B.P. 28262, Labège-Innopole, France. f.briand@physiogenex.com

J Lipid Res ; 51(4): 763-70, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19965597

Subject(s)

Benzoates/pharmacology; Benzylamines/pharmacology; Cholesterol/metabolism; Dyslipidemias/metabolism; Orphan Nuclear Receptors/agonists; Animals; Benzoates/therapeutic use; Benzylamines/therapeutic use; Bile Acids and Salts/analysis; Biological Transport/drug effects; Cardiovascular Diseases/drug therapy; Cell Line; Cholesterol/administration & dosage; Cholesterol/blood; Cricetinae; Disease Models, Animal; Dyslipidemias/blood; Dyslipidemias/etiology; Fatty Liver/etiology; Feces/chemistry; Gene Expression Regulation/drug effects; Intestinal Absorption/genetics; Lipid Metabolism/drug effects; Lipoproteins/blood; Lipoproteins, HDL/administration & dosage; Lipoproteins, HDL/blood; Lipoproteins, HDL/metabolism; Liver/drug effects; Liver/metabolism; Liver X Receptors; Macrophages/metabolism; Mesocricetus; Mice; RNA, Messenger/metabolism; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Benzoates / Benzylamines / Cholesterol / Dyslipidemias / Orphan Nuclear Receptors Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Lipid Res Year: 2010 Type: Article Affiliation country: France

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