Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia.

Friedberg, Jonathan W; Sharman, Jeff; Sweetenham, John; Johnston, Patrick B; Vose, Julie M; Lacasce, Ann; Schaefer-Cutillo, Julia; De Vos, Sven; Sinha, Rajni; Leonard, John P; Cripe, Larry D; Gregory, Stephanie A; Sterba, Michael P; Lowe, Ann M; Levy, Ronald; Shipp, Margaret A

Friedberg, Jonathan W; Sharman, Jeff; Sweetenham, John; Johnston, Patrick B; Vose, Julie M; Lacasce, Ann; Schaefer-Cutillo, Julia; De Vos, Sven; Sinha, Rajni; Leonard, John P; Cripe, Larry D; Gregory, Stephanie A; Sterba, Michael P; Lowe, Ann M; Levy, Ronald; Shipp, Margaret A.

Affiliation

Friedberg JW; James P. Wilmot Cancer Center, University of Rochester, NY 14642, USA. jonathan_friedberg@urmc.rochester.edu

Blood ; 115(13): 2578-85, 2010 Apr 01.

Article in En | MEDLINE | ID: mdl-19965662

Subject(s)

Antineoplastic Agents/therapeutic use; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Lymphoma, Non-Hodgkin/drug therapy; Neoplasm Proteins/antagonists & inhibitors; Oxazines/therapeutic use; Protein Kinase Inhibitors/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyridines/therapeutic use; Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacology; Cohort Studies; Diarrhea/chemically induced; Disease-Free Survival; Female; Hematologic Diseases/chemically induced; Humans; Hypertension/chemically induced; Intracellular Signaling Peptides and Proteins/physiology; Leukemia, Lymphocytic, Chronic, B-Cell/enzymology; Lymphoma, Non-Hodgkin/enzymology; Male; Middle Aged; Morpholines; Neoplasm Proteins/physiology; Oxazines/administration & dosage; Oxazines/adverse effects; Oxazines/pharmacology; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/adverse effects; Protein Kinase Inhibitors/pharmacology; Protein-Tyrosine Kinases/physiology; Pyridines/administration & dosage; Pyridines/adverse effects; Pyridines/pharmacology; Pyrimidines; Salvage Therapy; Syk Kinase; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Oxazines / Pyridines / Lymphoma, Non-Hodgkin / Protein-Tyrosine Kinases / Leukemia, Lymphocytic, Chronic, B-Cell / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Neoplasm Proteins / Antineoplastic Agents Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Aged80 Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: United States

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