Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma.

Morrison, Brian W; Doudican, Nicole A; Patel, Kirtesh R; Orlow, Seth J

Morrison, Brian W; Doudican, Nicole A; Patel, Kirtesh R; Orlow, Seth J.

Affiliation

Morrison BW; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York 10016, USA.

Melanoma Res ; 20(1): 11-20, 2010 Feb.

Article in En | MEDLINE | ID: mdl-19966593

Subject(s)

Apoptosis/drug effects; Copper Sulfate/pharmacology; Disulfiram/pharmacology; Melanoma/drug therapy; Reactive Oxygen Species/metabolism; Skin Neoplasms/drug therapy; Cell Growth Processes/drug effects; Cell Line, Tumor; Copper/metabolism; Humans; Melanoma/metabolism; Melanoma/pathology; Oxidative Stress/drug effects; Skin Neoplasms/metabolism; Skin Neoplasms/pathology

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Full text: 1 Database: MEDLINE Main subject: Skin Neoplasms / Reactive Oxygen Species / Apoptosis / Copper Sulfate / Disulfiram / Melanoma Limits: Humans Language: En Journal: Melanoma Res Journal subject: NEOPLASIAS Year: 2010 Type: Article Affiliation country: United States

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