BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4.

Suzuki, Momoko; Abe, Akihiro; Imagama, Shizuka; Nomura, Yuka; Tanizaki, Ryohei; Minami, Yosuke; Hayakawa, Fumihiko; Ito, Yoshie; Katsumi, Akira; Yamamoto, Kazuhito; Emi, Nobuhiko; Kiyoi, Hitoshi; Naoe, Tomoki

Suzuki, Momoko; Abe, Akihiro; Imagama, Shizuka; Nomura, Yuka; Tanizaki, Ryohei; Minami, Yosuke; Hayakawa, Fumihiko; Ito, Yoshie; Katsumi, Akira; Yamamoto, Kazuhito; Emi, Nobuhiko; Kiyoi, Hitoshi; Naoe, Tomoki.

Affiliation

Suzuki M; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Eur J Haematol ; 84(3): 229-38, 2010 Mar.

Article in En | MEDLINE | ID: mdl-20002159

Subject(s)

Drug Resistance, Neoplasm/physiology; Fusion Proteins, bcr-abl/antagonists & inhibitors; Neoplasm Proteins/physiology; Piperazines/pharmacology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology; Protein Kinase Inhibitors/pharmacology; Pyrimidines/pharmacology; Receptor, EphB4/physiology; ras Proteins/physiology; Benzamides; Cell Line, Tumor/drug effects; Cell Line, Tumor/enzymology; Enzyme Activation; Enzyme Induction; Ephrin-B2/genetics; Ephrin-B2/physiology; Female; Humans; Imatinib Mesylate; MAP Kinase Signaling System/physiology; Middle Aged; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/genetics; Phosphorylation/drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Protein Processing, Post-Translational/drug effects; RNA, Small Interfering/pharmacology; Receptor, EphB4/antagonists & inhibitors; Receptor, EphB4/genetics; Recurrence

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Full text: 1 Database: MEDLINE Main subject: Piperazines / Pyrimidines / Fusion Proteins, bcr-abl / Ras Proteins / Drug Resistance, Neoplasm / Receptor, EphB4 / Protein Kinase Inhibitors / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Neoplasm Proteins Limits: Female / Humans / Middle aged Language: En Journal: Eur J Haematol Journal subject: HEMATOLOGIA Year: 2010 Type: Article Affiliation country: Japan

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