A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation.

Skjoedt, Mikkel-Ole; Hummelshoj, Tina; Palarasah, Yaseelan; Honore, Christian; Koch, Claus; Skjodt, Karsten; Garred, Peter

Skjoedt, Mikkel-Ole; Hummelshoj, Tina; Palarasah, Yaseelan; Honore, Christian; Koch, Claus; Skjodt, Karsten; Garred, Peter.

Affiliation

Skjoedt MO; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark.

J Biol Chem ; 285(11): 8234-43, 2010 Mar 12.

Article in En | MEDLINE | ID: mdl-20053996

Subject(s)

Complement Activation/physiology; Lectins/metabolism; Mannose-Binding Lectins/metabolism; Mannose-Binding Protein-Associated Serine Proteases/genetics; Muscle, Skeletal/metabolism; Myocardium/metabolism; Alternative Splicing/physiology; Amino Acid Sequence; Animals; Antibody Specificity; CHO Cells; Cricetinae; Cricetulus; Cross Reactions; Humans; Immunohistochemistry; Isomerism; Mannose-Binding Protein-Associated Serine Proteases/chemistry; Mannose-Binding Protein-Associated Serine Proteases/immunology; Mannose-Binding Protein-Associated Serine Proteases/metabolism; Molecular Sequence Data; Molecular Weight; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Ficolins

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Full text: 1 Database: MEDLINE Main subject: Complement Activation / Muscle, Skeletal / Mannose-Binding Lectins / Mannose-Binding Protein-Associated Serine Proteases / Lectins / Myocardium Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Type: Article Affiliation country: Denmark

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