Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
Genes Dev
; 24(3): 256-64, 2010 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-20080940
ABSTRACT
The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.
Full text:
1
Database:
MEDLINE
Main subject:
Pituitary Gland
/
Thyroid Gland
/
Mitogen-Activated Protein Kinase 8
/
Hypothalamo-Hypophyseal System
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
2010
Type:
Article
Affiliation country:
United States