Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.

Shea, Barry S; Brooks, Sarah F; Fontaine, Benjamin A; Chun, Jerold; Luster, Andrew D; Tager, Andrew M

Shea, Barry S; Brooks, Sarah F; Fontaine, Benjamin A; Chun, Jerold; Luster, Andrew D; Tager, Andrew M.

Affiliation

Shea BS; Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

Am J Respir Cell Mol Biol ; 43(6): 662-73, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20081052

Subject(s)

Lung Injury/mortality; Lung Injury/pathology; Receptors, Lysosphingolipid/agonists; Vascular Diseases/complications; Animals; Bleomycin; Blood Coagulation/drug effects; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Endothelial Cells/pathology; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury/complications; Lung Injury/physiopathology; Lysophospholipids/metabolism; Male; Mice; Mice, Inbred C57BL; Oxadiazoles/pharmacology; Pneumonia/complications; Pneumonia/pathology; Pneumonia/physiopathology; Propylene Glycols/pharmacology; Pulmonary Alveoli/drug effects; Pulmonary Alveoli/pathology; Pulmonary Alveoli/physiopathology; Receptors, Lysosphingolipid/metabolism; Signal Transduction/drug effects; Sphingosine/analogs & derivatives; Sphingosine/metabolism; Sphingosine/pharmacology; Survival Analysis; Thiophenes/pharmacology; Vascular Diseases/pathology; Vascular Diseases/physiopathology; beta-Alanine/analogs & derivatives; beta-Alanine/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Vascular Diseases / Receptors, Lysosphingolipid / Lung Injury Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Type: Article Affiliation country: United States

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