Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity.

Mössner, Ekkehard; Brünker, Peter; Moser, Samuel; Püntener, Ursula; Schmidt, Carla; Herter, Sylvia; Grau, Roger; Gerdes, Christian; Nopora, Adam; van Puijenbroek, Erwin; Ferrara, Claudia; Sondermann, Peter; Jäger, Christiane; Strein, Pamela; Fertig, Georg; Friess, Thomas; Schüll, Christine; Bauer, Sabine; Dal Porto, Joseph; Del Nagro, Christopher; Dabbagh, Karim; Dyer, Martin J S; Poppema, Sibrand; Klein, Christian; Umaña, Pablo

Mössner, Ekkehard; Brünker, Peter; Moser, Samuel; Püntener, Ursula; Schmidt, Carla; Herter, Sylvia; Grau, Roger; Gerdes, Christian; Nopora, Adam; van Puijenbroek, Erwin; Ferrara, Claudia; Sondermann, Peter; Jäger, Christiane; Strein, Pamela; Fertig, Georg; Friess, Thomas; Schüll, Christine; Bauer, Sabine; Dal Porto, Joseph; Del Nagro, Christopher; Dabbagh, Karim; Dyer, Martin J S; Poppema, Sibrand; Klein, Christian; Umaña, Pablo.

Affiliation

Mössner E; GlycArt Biotechnology AG, Schlieren, Switzerland.

Blood ; 115(22): 4393-402, 2010 Jun 03.

Article in En | MEDLINE | ID: mdl-20194898

Subject(s)

Antibodies, Monoclonal/genetics; Antibodies, Monoclonal/pharmacology; Antigens, CD20/immunology; B-Lymphocytes/immunology; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibody-Dependent Cell Cytotoxicity; Cell Line, Tumor; Cytotoxicity, Immunologic; Female; Humans; Immunity, Cellular; Immunoglobulin Fc Fragments/genetics; Immunoglobulin Variable Region/genetics; In Vitro Techniques; Lymphocyte Depletion/methods; Lymphoma, B-Cell/immunology; Lymphoma, B-Cell/therapy; Lymphoma, Non-Hodgkin/immunology; Lymphoma, Non-Hodgkin/therapy; Macaca fascicularis; Mice; Mice, SCID; Neoplasm Transplantation; Protein Engineering; Receptors, IgG/immunology; Rituximab; Transplantation, Heterologous

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Full text: 1 Database: MEDLINE Main subject: B-Lymphocytes / Antigens, CD20 / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: Switzerland

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