Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.

Prohinar, Polonca; Rallabhandi, Prasad; Weiss, Jerrold P; Gioannini, Theresa L

Prohinar, Polonca; Rallabhandi, Prasad; Weiss, Jerrold P; Gioannini, Theresa L.

Affiliation

Prohinar P; Department of Internal Medicine, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, IA 52240, USA.

J Immunol ; 184(8): 4362-7, 2010 Apr 15.

Article in En | MEDLINE | ID: mdl-20212095

Subject(s)

Genetic Variation; Lymphocyte Antigen 96/genetics; Mutation, Missense; Polymorphism, Genetic; Toll-Like Receptor 4/genetics; Amino Acid Substitution/genetics; Amino Acid Substitution/immunology; Cell Line; Dose-Response Relationship, Immunologic; Endotoxins/metabolism; Endotoxins/pharmacology; Genetic Variation/immunology; Haplotypes; Humans; Lipopolysaccharides/metabolism; Lipopolysaccharides/pharmacology; Lymphocyte Antigen 96/biosynthesis; Lymphocyte Antigen 96/metabolism; Mutation, Missense/immunology; Polymorphism, Genetic/immunology; Protein Binding/genetics; Protein Binding/immunology; Protein Structure, Tertiary/genetics; Toll-Like Receptor 4/agonists; Toll-Like Receptor 4/biosynthesis; Toll-Like Receptor 4/metabolism

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Full text: 1 Database: MEDLINE Main subject: Polymorphism, Genetic / Genetic Variation / Mutation, Missense / Lymphocyte Antigen 96 / Toll-Like Receptor 4 Limits: Humans Language: En Journal: J Immunol Year: 2010 Type: Article Affiliation country: United States

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