Association between TIM-1 gene polymorphisms and allergic rhinitis in a Han Chinese population.
J Investig Allergol Clin Immunol
; 20(1): 3-8, 2010.
Article
in En
| MEDLINE
| ID: mdl-20232767
ABSTRACT
BACKGROUND:
TIM-1, a member of the T cell immunoglobulin and mucin (TIM) domain family, is involved in T-cell differentiation and has been implicated in allergic diseases. An association between TIM-1 and allergic rhinitis, however, has not been established.OBJECTIVE:
To investigate whether TIM-1 gene polymorphisms were associated with allergic rhinitis in a Han Chinese population.METHODS:
Two TIM-1 promoter single nucleotide polymorphisms (SNPs), -416G>C and -1454G>A, were examined in 185 allergic rhinitis patients of Han Chinese ethnicity using polymerase chain reaction (PCR) and restriction fragment length polymorphism. Additionally, exon 4 insertion/deletion polymorphisms in the TIM-1 gene were analyzed by PCR, polyacrylamide gel electrophoresis, and silver staining. The relationship between gene polymorphisms and serum specific IgE levels in this Han Chinese population was also evaluated.RESULTS:
We found that the -416G>C and -1454G>A SNPs were associated with allergic rhinitis susceptibility in this Han Chinese population. No statistically significant differences in the distribution of genotype or allele frequencies of 5383_5397ins/del and 5509_5511delCAA in exon 4 were observed. The -416G>C and -1454G>A SNPs were associated with the level of serum IgE specific to house dust mites in patients with allergic rhinitis.CONCLUSIONS:
These results suggest that TIM-1 gene polymorphisms (-416G>C and -1454G>A) are associated with allergic rhinitis susceptibility in a Han Chinese population.
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Database:
MEDLINE
Main subject:
Receptors, Virus
/
Membrane Glycoproteins
/
Rhinitis, Allergic, Perennial
/
Rhinitis, Allergic, Seasonal
/
Polymorphism, Single Nucleotide
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Investig Allergol Clin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2010
Type:
Article
Affiliation country:
China