Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals.

Kim, Soong Ho; Fraser, Paul E; Westaway, David; St George-Hyslop, Peter H; Ehrlich, Michelle E; Gandy, Sam

Kim, Soong Ho; Fraser, Paul E; Westaway, David; St George-Hyslop, Peter H; Ehrlich, Michelle E; Gandy, Sam.

Affiliation

Kim SH; Departments of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA.

J Neurosci ; 30(11): 3870-5, 2010 Mar 17.

Article in En | MEDLINE | ID: mdl-20237257

Subject(s)

Alzheimer Disease/metabolism; Amyloid beta-Peptides/biosynthesis; Amyloid beta-Peptides/metabolism; Nerve Endings/metabolism; Peptide Fragments/biosynthesis; Peptide Fragments/metabolism; Receptors, Metabotropic Glutamate/physiology; Alzheimer Disease/enzymology; Amino Acids/pharmacology; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Protein Precursor/biosynthesis; Amyloid beta-Protein Precursor/genetics; Animals; Humans; Methoxyhydroxyphenylglycol/analogs & derivatives; Methoxyhydroxyphenylglycol/pharmacology; Mice; Mice, Transgenic; Nerve Endings/drug effects; Nerve Endings/enzymology; Receptors, Metabotropic Glutamate/agonists; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Signal Transduction/drug effects; Signal Transduction/physiology; Xanthenes/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Receptors, Metabotropic Glutamate / Alzheimer Disease / Nerve Endings Limits: Animals / Humans Language: En Journal: J Neurosci Year: 2010 Type: Article Affiliation country: United States

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