Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.

Krysov, Sergey; Potter, Kathleen N; Mockridge, C Ian; Coelho, Vania; Wheatley, Isla; Packham, Graham; Stevenson, Freda K

Krysov, Sergey; Potter, Kathleen N; Mockridge, C Ian; Coelho, Vania; Wheatley, Isla; Packham, Graham; Stevenson, Freda K.

Affiliation

Krysov S; Molecular Immunology Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, United Kingdom.

Blood ; 115(21): 4198-205, 2010 May 27.

Article in En | MEDLINE | ID: mdl-20237321

Subject(s)

Immunoglobulin M/chemistry; Immunoglobulin M/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/immunology; Receptors, Antigen, B-Cell/chemistry; Receptors, Antigen, B-Cell/metabolism; Antigen Presentation; B-Lymphocytes/immunology; Case-Control Studies; Glycosylation; Humans; Immunoglobulin M/genetics; Immunoglobulin mu-Chains/chemistry; Immunoglobulin mu-Chains/genetics; Immunoglobulin mu-Chains/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Models, Immunological; Mutation; Polysaccharides/chemistry; Polysaccharides/genetics; Prognosis; Receptors, Antigen, B-Cell/genetics

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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin M / Receptors, Antigen, B-Cell / Leukemia, Lymphocytic, Chronic, B-Cell Type of study: Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: United kingdom

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