Focal laser ablation for prostate cancer followed by radical prostatectomy: validation of focal therapy and imaging accuracy.
Eur Urol
; 57(6): 1111-4, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20346578
ABSTRACT
An increased incidence of low-risk prostate cancer (PCa) has led investigators to develop focal therapy as a management option for PCa. We evaluated the effects of focal laser ablation (FLA) on PCa tissue and the accuracy of magnetic resonance imaging (MRI) in determining ablated lesion volume by comparing the whole-mount histology and MRI in four patients that underwent FLA followed by radical prostatectomy. Ablated areas were characterized by homogeneous coagulation necrosis. The MRI-calculated ablated volume correlated well with histopathology. We found that FLA creates confluent ablation with no evidence of viable cells in treated regions. Postablation MRI is able to determine the ablation accurately.
Full text:
1
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Magnetic Resonance Imaging
/
Laser Therapy
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Urol
Year:
2010
Type:
Article
Affiliation country:
Canada