The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.

LaPorte, Matthew G; Draper, Tandy L; Miller, Lori E; Blackledge, Charles W; Leister, Lara K; Amparo, Eugene; Hussey, Alison R; Young, Dorothy C; Chunduru, Srinivas K; Benetatos, Christopher A; Rhodes, Gerry; Gopalsamy, Ariamala; Herbertz, Torsten; Burns, Christopher J; Condon, Stephen M

LaPorte, Matthew G; Draper, Tandy L; Miller, Lori E; Blackledge, Charles W; Leister, Lara K; Amparo, Eugene; Hussey, Alison R; Young, Dorothy C; Chunduru, Srinivas K; Benetatos, Christopher A; Rhodes, Gerry; Gopalsamy, Ariamala; Herbertz, Torsten; Burns, Christopher J; Condon, Stephen M.

Affiliation

LaPorte MG; University of Pittsburgh, Center for Chemical Methodologies and Library Development, Pittsburgh, PA 15260, USA. mgl12@pitt.edu

Bioorg Med Chem Lett ; 20(9): 2968-73, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20347591

Subject(s)

Antiviral Agents/chemistry; Enzyme Inhibitors/chemistry; Indoles/chemistry; Pyrans/chemistry; Viral Nonstructural Proteins/antagonists & inhibitors; Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Binding Sites; Crystallography, X-Ray; Drug Discovery; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Indoles/chemical synthesis; Indoles/pharmacology; Pyrans/chemical synthesis; Pyrans/pharmacology; Structure-Activity Relationship; Viral Nonstructural Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Pyrans / Viral Nonstructural Proteins / Enzyme Inhibitors / Indoles Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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