Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.

Poirier, Nicolas; Azimzadeh, Agnes M; Zhang, Tianshu; Dilek, Nahzli; Mary, Caroline; Nguyen, Bao; Tillou, Xavier; Wu, Guosheng; Reneaudin, Karine; Hervouet, Jeremy; Martinet, Bernard; Coulon, Flora; Allain-Launay, Emma; Karam, Georges; Soulillou, Jean-Paul; Pierson, Richard N; Blancho, Gilles; Vanhove, Bernard

Poirier, Nicolas; Azimzadeh, Agnes M; Zhang, Tianshu; Dilek, Nahzli; Mary, Caroline; Nguyen, Bao; Tillou, Xavier; Wu, Guosheng; Reneaudin, Karine; Hervouet, Jeremy; Martinet, Bernard; Coulon, Flora; Allain-Launay, Emma; Karam, Georges; Soulillou, Jean-Paul; Pierson, Richard N; Blancho, Gilles; Vanhove, Bernard.

Affiliation

Poirier N; INSERM U643, ITERT-Uro-Nephro, Centaure Network, CHU Nantes, 30 Bl J. Monnet, 44093 Nantes, France.

Sci Transl Med ; 2(17): 17ra10, 2010 Feb 03.

Article in En | MEDLINE | ID: mdl-20371478

Subject(s)

Antigens, CD/metabolism; CD28 Antigens/metabolism; Organ Transplantation/methods; Animals; B7-1 Antigen/biosynthesis; B7-2 Antigen/biosynthesis; CTLA-4 Antigen; Calcineurin/metabolism; Graft Survival; Humans; Immune System; Lymphocytes/cytology; Macaca fascicularis; Papio; T-Lymphocytes, Regulatory/cytology

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Full text: 1 Database: MEDLINE Main subject: Antigens, CD / Organ Transplantation / CD28 Antigens Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2010 Type: Article Affiliation country: France

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