Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.

Arun, Peethambaran; Madhavarao, Chikkathur N; Moffett, John R; Hamilton, Kristen; Grunberg, Neil E; Ariyannur, Prasanth S; Gahl, William A; Anikster, Yair; Mog, Steven; Hallows, William C; Denu, John M; Namboodiri, Aryan M A

Arun, Peethambaran; Madhavarao, Chikkathur N; Moffett, John R; Hamilton, Kristen; Grunberg, Neil E; Ariyannur, Prasanth S; Gahl, William A; Anikster, Yair; Mog, Steven; Hallows, William C; Denu, John M; Namboodiri, Aryan M A.

Affiliation

Arun P; Department of Anatomy, Physiology and Genetics, Neuroscience Program and Molecular and Cell Biology Program, Uniformed Services University of the Health Sciences, Building C, Bethesda, MD 20814, USA.

J Inherit Metab Dis ; 33(3): 195-210, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20464498

Subject(s)

Acetates/therapeutic use; Aspartic Acid/analogs & derivatives; Canavan Disease/therapy; Mutation; Animals; Aspartic Acid/metabolism; Aspartic Acid/therapeutic use; Brain/metabolism; Disease Models, Animal; Female; Heterozygote; Lipids/chemistry; Male; Myelin Sheath/chemistry; Phenotype; Rats; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Aspartic Acid / Canavan Disease / Acetates / Mutation Limits: Animals Language: En Journal: J Inherit Metab Dis Year: 2010 Type: Article Affiliation country: United States

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