Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets.

Piazza, Matteo; Damore, Gaetana; Costa, Barbara; Gioannini, Theresa L; Weiss, Jerrold P; Peri, Francesco

Piazza, Matteo; Damore, Gaetana; Costa, Barbara; Gioannini, Theresa L; Weiss, Jerrold P; Peri, Francesco.

Affiliation

Piazza M; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy.

Innate Immun ; 17(3): 293-301, 2011 Feb.

Article in En | MEDLINE | ID: mdl-20472612

Subject(s)

Hemin/pharmacology; Toll-Like Receptor 4/agonists; Toll-Like Receptor 4/antagonists & inhibitors; Endotoxins/pharmacology; HEK293 Cells; Hemin/analogs & derivatives; Hemin/immunology; Hemin/metabolism; Humans; Immunity, Innate; Interleukin-8/biosynthesis; Interleukin-8/genetics; Lipopolysaccharide Receptors/metabolism; Lymphocyte Antigen 96/metabolism; Oxidation-Reduction; Protein Binding/drug effects; Signal Transduction/drug effects; Signal Transduction/immunology; Toll-Like Receptor 4/metabolism

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Full text: 1 Database: MEDLINE Main subject: Toll-Like Receptor 4 / Hemin Limits: Humans Language: En Journal: Innate Immun Journal subject: ALERGIA E IMUNOLOGIA / BACTERIOLOGIA Year: 2011 Type: Article Affiliation country: Italy

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