Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents.

Lin, Chun-Jung; Tai, Ying; Huang, Miao-Tzu; Tsai, Yuan-Feen; Hsu, Hao-Jui; Tzen, Kai-Yuan; Liou, Horng-Huei

Lin, Chun-Jung; Tai, Ying; Huang, Miao-Tzu; Tsai, Yuan-Feen; Hsu, Hao-Jui; Tzen, Kai-Yuan; Liou, Horng-Huei.

Affiliation

Lin CJ; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. clementumich@ntu.edu.tw

J Neurochem ; 114(3): 717-27, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20477935

Subject(s)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacokinetics; Blood-Brain Barrier/metabolism; Dopamine/physiology; Endothelial Cells/metabolism; Octamer Transcription Factor-1/metabolism; Organic Cation Transport Proteins/metabolism; Animals; Binding, Competitive/physiology; Biological Transport, Active; Capillaries/cytology; Capillaries/metabolism; Cells, Cultured; Dopamine/toxicity; Humans; Male; Mice; Mice, Inbred C57BL; Neurotoxins/pharmacokinetics; Organic Cation Transporter 2; Parkinsonian Disorders/metabolism; Parkinsonian Disorders/physiopathology; Rats; Rats, Wistar

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Full text: 1 Database: MEDLINE Main subject: Blood-Brain Barrier / Dopamine / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Organic Cation Transport Proteins / Endothelial Cells / Octamer Transcription Factor-1 Limits: Animals / Humans / Male Language: En Journal: J Neurochem Year: 2010 Type: Article Affiliation country: Taiwan

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