IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure.
Scand J Immunol
; 71(6): 447-51, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20500697
ABSTRACT
We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1beta, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-gamma, tumour necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta were measured simultaneously in CSF supernatants from children with encephalopathy (n = 8), febrile seizure (n = 16) and fever without neurological complications (n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage.
Full text:
1
Database:
MEDLINE
Main subject:
Interleukins
/
Seizures, Febrile
/
Encephalitis
Type of study:
Prognostic_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Scand J Immunol
Year:
2010
Type:
Article
Affiliation country:
Japan