Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells.

Lee, Myung Sun; Cha, Eun Young; Thuong, Phuong Thien; Kim, Ji Yeon; Ahn, Moon Sang; Sul, Ji Young

Lee, Myung Sun; Cha, Eun Young; Thuong, Phuong Thien; Kim, Ji Yeon; Ahn, Moon Sang; Sul, Ji Young.

Affiliation

Lee MS; Regional Cancer Institute, Chungnam National University Hospital, Daejeon 301-721, Republic of Korea.

Biol Pharm Bull ; 33(6): 931-7, 2010.

Article in En | MEDLINE | ID: mdl-20522955

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Cell Cycle/drug effects; Plant Extracts/pharmacology; Receptor, ErbB-2/metabolism; Stomach Neoplasms/drug therapy; Triterpenes/pharmacology; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Antineoplastic Agents, Phytogenic/therapeutic use; Caspase 3/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression/drug effects; Genes, erbB-2; Humans; Phytotherapy; Plant Extracts/therapeutic use; Poly(ADP-ribose) Polymerases/metabolism; Receptor, ErbB-2/genetics; Signal Transduction/drug effects; Triterpenes/therapeutic use

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Database: MEDLINE Main subject: Stomach Neoplasms / Triterpenes / Plant Extracts / Cell Cycle / Apoptosis / Receptor, ErbB-2 / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2010 Type: Article

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