Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

Aronchik, Ida; Bjeldanes, Leonard F; Firestone, Gary L

Aronchik, Ida; Bjeldanes, Leonard F; Firestone, Gary L.

Affiliation

Aronchik I; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3200, USA.

Cancer Res ; 70(12): 4961-71, 2010 Jun 15.

Article in En | MEDLINE | ID: mdl-20530686

Subject(s)

Breast Neoplasms/metabolism; CD40 Antigens/metabolism; Indoles/pharmacology; NF-kappa B/metabolism; Pancreatic Elastase/antagonists & inhibitors; TNF Receptor-Associated Factor 1/metabolism; TNF Receptor-Associated Factor 3/metabolism; Transcription, Genetic/drug effects; Blotting, Western; Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; CD40 Antigens/genetics; Female; Flow Cytometry; Fluorescent Antibody Technique; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Luciferases/metabolism; NF-kappa B/genetics; Pancreatic Elastase/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; TNF Receptor-Associated Factor 1/genetics; TNF Receptor-Associated Factor 3/genetics; Tumor Cells, Cultured

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Breast Neoplasms / Pancreatic Elastase / NF-kappa B / CD40 Antigens / TNF Receptor-Associated Factor 1 / TNF Receptor-Associated Factor 3 / Indoles Limits: Female / Humans Language: En Journal: Cancer Res Year: 2010 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google