CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction.

Jujo, Kentaro; Hamada, Hiromichi; Iwakura, Atsushi; Thorne, Tina; Sekiguchi, Haruki; Clarke, Trevor; Ito, Aiko; Misener, Sol; Tanaka, Toshikazu; Klyachko, Ekaterina; Kobayashi, Koichi; Tongers, Jörn; Roncalli, Jérôme; Tsurumi, Yukio; Hagiwara, Nobuhisa; Losordo, Douglas W

Jujo, Kentaro; Hamada, Hiromichi; Iwakura, Atsushi; Thorne, Tina; Sekiguchi, Haruki; Clarke, Trevor; Ito, Aiko; Misener, Sol; Tanaka, Toshikazu; Klyachko, Ekaterina; Kobayashi, Koichi; Tongers, Jörn; Roncalli, Jérôme; Tsurumi, Yukio; Hagiwara, Nobuhisa; Losordo, Douglas W.

Affiliation

Jujo K; Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Proc Natl Acad Sci U S A ; 107(24): 11008-13, 2010 Jun 15.

Article in En | MEDLINE | ID: mdl-20534467

Subject(s)

Bone Marrow Transplantation; Myocardial Infarction/therapy; Receptors, CXCR4/antagonists & inhibitors; Animals; Base Sequence; Benzylamines; Blood Cell Count; Capillaries/drug effects; Capillaries/pathology; Cyclams; DNA Primers/genetics; Endothelial Cells/drug effects; Endothelial Cells/pathology; Female; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/pathology; Heterocyclic Compounds/pharmacology; Male; Matrix Metalloproteinase 9/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocardial Infarction/pathology; Myocardial Infarction/physiopathology; Neovascularization, Physiologic/drug effects; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Database: MEDLINE Main subject: Bone Marrow Transplantation / Receptors, CXCR4 / Myocardial Infarction Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2010 Type: Article Affiliation country: United States

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