Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.

Dhar, Neeraj; McKinney, John D

Dhar, Neeraj; McKinney, John D.

Affiliation

Dhar N; Global Health Institute, Swiss Federal Institute of Technology EPFL, 1015 Lausanne, Switzerland. neeraj.dhar@epfl.ch

Proc Natl Acad Sci U S A ; 107(27): 12275-80, 2010 Jul 06.

Article in En | MEDLINE | ID: mdl-20566858

Subject(s)

Isoniazid/pharmacology; Mutation; Mycobacterium tuberculosis/drug effects; Tuberculosis/drug therapy; ATP-Binding Cassette Transporters/genetics; Animals; Antitubercular Agents/pharmacology; Bacterial Proteins/genetics; Cells, Cultured; Drug Resistance, Bacterial/genetics; GTP-Binding Proteins/genetics; GTP-Binding Proteins/metabolism; Genetic Complementation Test; Macrophages/cytology; Macrophages/drug effects; Macrophages/microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbial Sensitivity Tests; Mycobacterium tuberculosis/genetics; Mycobacterium tuberculosis/growth & development; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Tuberculosis/microbiology

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Full text: 1 Database: MEDLINE Main subject: Tuberculosis / Isoniazid / Mutation / Mycobacterium tuberculosis Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2010 Type: Article Affiliation country: Switzerland

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