Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

Ohtsuka, Tatsuyuki; Yoshikawa, Takahiro; Kozakai, Kazumasa; Tsuneto, Yumi; Uno, Yasuhiro; Utoh, Masahiro; Yamazaki, Hiroshi; Kume, Toshiyuki

Ohtsuka, Tatsuyuki; Yoshikawa, Takahiro; Kozakai, Kazumasa; Tsuneto, Yumi; Uno, Yasuhiro; Utoh, Masahiro; Yamazaki, Hiroshi; Kume, Toshiyuki.

Affiliation

Ohtsuka T; DMPK Research Laboratory, 2-2-50 Kawagishi, Toda, Saitama, Japan. ohtsuka.tatsuyuki@ma.mt-pharma.co.jp

Drug Metab Dispos ; 38(10): 1806-13, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20584745

Subject(s)

Alprazolam/pharmacokinetics; Cytochrome P-450 CYP3A/biosynthesis; Intestine, Small/enzymology; Liver/enzymology; Administration, Oral; Alprazolam/administration & dosage; Alprazolam/blood; Alprazolam/metabolism; Animals; Cytochrome P-450 CYP3A/genetics; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/genetics; Hepatocytes/enzymology; Hepatocytes/metabolism; Humans; Injections, Intravenous; Intestine, Small/metabolism; Liver/metabolism; Macaca fascicularis; Male; Metabolic Clearance Rate; Microsomes/enzymology; Microsomes/metabolism; Models, Animal; Predictive Value of Tests; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Transfection

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Full text: 1 Database: MEDLINE Main subject: Alprazolam / Cytochrome P-450 CYP3A / Intestine, Small / Liver Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2010 Type: Article Affiliation country: Japan

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