A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs.

Grey, Finn; Tirabassi, Rebecca; Meyers, Heather; Wu, Guanming; McWeeney, Shannon; Hook, Lauren; Nelson, Jay A

Grey, Finn; Tirabassi, Rebecca; Meyers, Heather; Wu, Guanming; McWeeney, Shannon; Hook, Lauren; Nelson, Jay A.

Affiliation

Grey F; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. finn.grey@roslin.ed.ac.uk

PLoS Pathog ; 6(6): e1000967, 2010 Jun 24.

Article in En | MEDLINE | ID: mdl-20585629

Subject(s)

5' Untranslated Regions/genetics; Cell Cycle Proteins/genetics; Gene Expression Regulation; MicroRNAs/genetics; RNA, Messenger/genetics; RNA, Viral/genetics; Virus Replication/genetics; Blotting, Western; Cells, Cultured; Cyclins/antagonists & inhibitors; Cyclins/genetics; Cyclins/metabolism; Cytomegalovirus/physiology; Cytomegalovirus Infections/genetics; Cytomegalovirus Infections/virology; Down-Regulation; Humans; Kidney/cytology; Kidney/metabolism; Luciferases/metabolism; RNA-Induced Silencing Complex/genetics; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Virus Replication / RNA, Messenger / RNA, Viral / Gene Expression Regulation / Cell Cycle Proteins / 5' Untranslated Regions / MicroRNAs Limits: Humans Language: En Journal: PLoS Pathog Year: 2010 Type: Article Affiliation country: United States

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