The potent synthetic androgens, dimethandrolone (7&#945;,11ß-dimethyl-19-nortestosterone) and 11ß-methyl-19-nortestosterone, do not require 5&#945;-reduction to exert their maximal androgenic effects.

Attardi, Barbara J; Hild, Sheri A; Koduri, Sailaja; Pham, Trung; Pessaint, Laurent; Engbring, Jean; Till, Bruce; Gropp, David; Semon, Anne; Reel, Jerry R

The potent synthetic androgens, dimethandrolone (7α,11ß-dimethyl-19-nortestosterone) and 11ß-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects.

Attardi, Barbara J; Hild, Sheri A; Koduri, Sailaja; Pham, Trung; Pessaint, Laurent; Engbring, Jean; Till, Bruce; Gropp, David; Semon, Anne; Reel, Jerry R.

Affiliation

Attardi BJ; Division of Reproductive Endocrinology and Toxicology, BIOQUAL, Inc, 9600 Medical Center Dr, Rockville, MD 20850, United States. bjattardi@bioqual.com

J Steroid Biochem Mol Biol ; 122(4): 212-8, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20599615

Subject(s)

Nandrolone/analogs & derivatives; Testosterone Congeners/pharmacology; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/metabolism; Animals; Dihydrotestosterone/pharmacology; Dihydrotestosterone/therapeutic use; Humans; Male; Nandrolone/pharmacology; Nandrolone/therapeutic use; Organ Size/drug effects; Prostate/drug effects; Rats; Rats, Sprague-Dawley; Receptors, Androgen/metabolism; Seminal Vesicles/drug effects; Testosterone/pharmacology; Testosterone/therapeutic use; Testosterone Congeners/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Testosterone Congeners / Nandrolone Limits: Animals / Humans / Male Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2010 Type: Article Affiliation country: United States

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