Stabilization of anionic and neutral forms of a fluorophoric ligand at the active site of human carbonic anhydrase I.

Manokaran, Sumathra; Banerjee, Jayati; Mallik, Sanku; Srivastava, D K

Manokaran, Sumathra; Banerjee, Jayati; Mallik, Sanku; Srivastava, D K.

Affiliation

Manokaran S; Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58105, USA.

Biochim Biophys Acta ; 1804(10): 1965-73, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20620244

Subject(s)

Carbonic Anhydrase I/chemistry; Dansyl Compounds/chemistry; Fluorescent Dyes/chemistry; Catalytic Domain; Humans; Hydrogen-Ion Concentration; Kinetics; Ligands; Models, Chemical; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics

Key words

Dansylamide; Fluorophore; Human carbonic anhydrase-I; Inhibitor design; Sulfonamide; ligand binding

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Full text: 1 Database: MEDLINE Main subject: Carbonic Anhydrase I / Dansyl Compounds / Fluorescent Dyes Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2010 Type: Article Affiliation country: United States

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