Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

Albizu, Laura; Cottet, Martin; Kralikova, Michaela; Stoev, Stoytcho; Seyer, René; Brabet, Isabelle; Roux, Thomas; Bazin, Hervé; Bourrier, Emmanuel; Lamarque, Laurent; Breton, Christophe; Rives, Marie-Laure; Newman, Amy; Javitch, Jonathan; Trinquet, Eric; Manning, Maurice; Pin, Jean-Philippe; Mouillac, Bernard; Durroux, Thierry

Albizu, Laura; Cottet, Martin; Kralikova, Michaela; Stoev, Stoytcho; Seyer, René; Brabet, Isabelle; Roux, Thomas; Bazin, Hervé; Bourrier, Emmanuel; Lamarque, Laurent; Breton, Christophe; Rives, Marie-Laure; Newman, Amy; Javitch, Jonathan; Trinquet, Eric; Manning, Maurice; Pin, Jean-Philippe; Mouillac, Bernard; Durroux, Thierry.

Affiliation

Albizu L; Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Montpellier, France.

Nat Chem Biol ; 6(8): 587-94, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20622858

Subject(s)

Fluorescence Resonance Energy Transfer/methods; Oligopeptides/chemistry; Receptors, G-Protein-Coupled/metabolism; Algorithms; Animals; Antidiuretic Hormone Receptor Antagonists; COS Cells; Cell Line; Chlorocebus aethiops; Dimerization; Dopamine D2 Receptor Antagonists; Female; Fluorescent Dyes; Ligands; Mammary Glands, Animal/metabolism; Models, Molecular; Oligopeptides/metabolism; Radioligand Assay; Rats; Receptors, Dopamine D2/agonists; Receptors, Dopamine D2/metabolism; Receptors, G-Protein-Coupled/agonists; Receptors, G-Protein-Coupled/antagonists & inhibitors; Receptors, Oxytocin/agonists; Receptors, Oxytocin/antagonists & inhibitors; Receptors, Oxytocin/metabolism; Receptors, Vasopressin/agonists; Receptors, Vasopressin/metabolism

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Full text: 1 Database: MEDLINE Main subject: Oligopeptides / Fluorescence Resonance Energy Transfer / Receptors, G-Protein-Coupled Limits: Animals Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2010 Type: Article Affiliation country: France

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