Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

Garin, Alexandre; Meyer-Hermann, Michael; Contie, Mathias; Figge, Marc Thilo; Buatois, Vanessa; Gunzer, Matthias; Toellner, Kai-Michael; Elson, Greg; Kosco-Vilbois, Marie H

Garin, Alexandre; Meyer-Hermann, Michael; Contie, Mathias; Figge, Marc Thilo; Buatois, Vanessa; Gunzer, Matthias; Toellner, Kai-Michael; Elson, Greg; Kosco-Vilbois, Marie H.

Affiliation

Garin A; NovImmune SA, 14 chemin des Aulx, 1228 Plan les Ouates, Switzerland.

Immunity ; 33(1): 84-95, 2010 Jul 23.

Article in En | MEDLINE | ID: mdl-20643339

Subject(s)

B-Lymphocytes/metabolism; Dendritic Cells, Follicular/metabolism; Germinal Center/metabolism; Toll-Like Receptor 4/metabolism; Animals; Antibodies, Blocking; Antibody Affinity; Antigens, Differentiation/biosynthesis; B-Lymphocytes/immunology; B-Lymphocytes/pathology; Bone Marrow Transplantation; Cell Differentiation/genetics; Cell Differentiation/immunology; Dendritic Cells, Follicular/pathology; Germinal Center/pathology; Immunoglobulin Class Switching/genetics; Immunoglobulin Class Switching/immunology; Immunologic Memory; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mutation/genetics; Radiation Chimera; Signal Transduction/immunology; Somatic Hypermutation, Immunoglobulin/genetics; Somatic Hypermutation, Immunoglobulin/immunology; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/immunology

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Full text: 1 Database: MEDLINE Main subject: B-Lymphocytes / Germinal Center / Dendritic Cells, Follicular / Toll-Like Receptor 4 Type of study: Prognostic_studies / Qualitative_research Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2010 Type: Article Affiliation country: Switzerland

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