Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.

Koyanagi, Madoka; Kerns, Julie A; Chung, Linda; Zhang, Yan; Brown, Scott; Moldoveanu, Tudor; Malik, Harmit S; Bix, Mark

Koyanagi, Madoka; Kerns, Julie A; Chung, Linda; Zhang, Yan; Brown, Scott; Moldoveanu, Tudor; Malik, Harmit S; Bix, Mark.

Affiliation

Koyanagi M; Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

BMC Evol Biol ; 10: 223, 2010 Jul 22.

Article in En | MEDLINE | ID: mdl-20649995

Subject(s)

Evolution, Molecular; Interleukin-4/genetics; Mice/genetics; Receptors, Interleukin-4/genetics; Selection, Genetic; Amino Acid Sequence; Animals; Genetic Variation; Humans; Likelihood Functions; Mammals/genetics; Mice, Inbred BALB C; Molecular Sequence Data; Phylogeny; Protein Binding; Protein Structure, Secondary; Sequence Alignment; Sequence Analysis, DNA; Species Specificity

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Full text: 1 Database: MEDLINE Main subject: Selection, Genetic / Interleukin-4 / Evolution, Molecular / Receptors, Interleukin-4 / Mice Limits: Animals / Humans Language: En Journal: BMC Evol Biol Journal subject: BIOLOGIA Year: 2010 Type: Article Affiliation country: United States

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