Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection.
J Virol
; 84(20): 10907-12, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20686015
ABSTRACT
The kinetics of CD8(+) T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-specific CD8(+) T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4(+) T cells early after SIV infection.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Products, rev
/
Simian Immunodeficiency Virus
/
Gene Products, vpr
/
CD8-Positive T-Lymphocytes
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2010
Type:
Article
Affiliation country:
United States